Perpustakaan Digital

This Special Issue focuses on the use of MRI in diagnosing and managing of prostate cancer. It is estimated that one in nine men will be diagnosed with prostate cancer in their lifetime, and magnetic resonance imaging (MRI) is a powerful imaging technique often used to diagnose and monitor prostate cancer. This Special Issue covers topics such as using MRI for prostate cancer screening and the role of MRI in the staging, prognosis, and treatment of prostate cancer. It also includes a review of the latest research and clinical applications of MRI-based radiomics in prostate cancer diagnosis. This Special Issue provides an invaluable resource for researchers, clinicians, and patients interested in the use of MRI for diagnosing and managing of prostate cancer.

The growing resistance of microorganisms, especially among clinical strains, to popular antibiotics used in the treatment of infectious diseases is a huge global problem. The problem with MDR (multidrug-resistant) strains is associated with significant mortality caused by these pathogenic microorganisms, especially in hospital environments. The search for new compounds of natural origin is crucial in solving this problem. Extraction is a simple method to isolate various compounds from raw plant material. Furthermore, different plant extracts have high biological activity, comparable to that of known drugs. However, in search of novel plant-derived compounds characterized with stronger biological activity than plant extracts, chemical modifications of natural compounds are helpful. Additionally, articles that present alternative methods of obtaining natural compounds with antimicrobial activity, e.g., as a result of biotransformation using whole cells of microorganisms or pure enzymes

As the healthcare sector adapts to the evolving standards of Industry 4.0, there is a pressing need for more intelligent, automated, and efficient solutions. This evolution demands cutting-edge research that meets the increasing technical and functional requirements of modern medical applications. The integration of advanced mechatronic systems is essential to create value-added products that are not only highly functional, but also seamlessly adaptable to dynamic healthcare environments. The scope of this reprint includes contributions that leverage mechatronic principles across a range of domains—such as smart manufacturing, rapid prototyping, artificial intelligence, and adaptive materials—to foster innovation in medical engineering. Whether through enhancing clinical robotic systems, streamlining automated production lines for medical devices, or developing next-generation diagnostic and therapeutic tools, mechatronics offers transformative potential.

Nowhere is the explosion in comprehensive genomic testing more evident than in oncology. Multiple consensus guidelines now recommend molecular testing as the standard of care for most metastatic tumors. To aid in the advancement of this rapidly changing field, we intend this Special Issue of JPM to focus on technical developments in the genomic profiling of cancer, detail promising somatic alterations that either are, or have a high likelihood of being, relevant in the near future, and to address issues related to the pricing and value of these tests.The last few years have seen the cost of molecular testing decrease by orders of magnitude. In 2018, we saw the first “site-agnostic” drug approvals in cancer (for microsatellite unstable cancer (PD-1 inhibitors) and NTRK-fusions (TRK inhibitors)). Research on targetable mutations, determination of genetic “signatures” that can use multiple individual genes/pathways, development of targeted therapy, and insight into the value of new tech

The purpose of this reprint is to explain the health-related factors, mechanisms, and consequences of mental health problems associated with chronic sleep disorders. The reprint presents how insomnia and sleep disorders affect mental health across genders and high-risk groups, including populations such as university students, healthcare workers, firefighters, people with ADHD symptoms, people with chronic spinal pain, and patients of forensic hospitals suffering from chronic neuropsychiatric disorders. By integrating findings from diverse demographic and clinical groups, the reprint provides insight into how chronic sleep disorders intersect with mental health, offering guidance for targeted interventions and public health policies. The reprint highlights the impact of contextual factors, including the COVID-19 pandemic, occupational stress, and digital media exposure, on sleep hygiene and mental well-being. The researchers examined how the currently observed risks associated with the use of modern technology, such as mobile screen addiction and online gaming disorder, impact specific aspects of mental health, including insomnia, stress, anxiety, and depression. Such a multifaced and comprehensive approach can be helpful for health-related organizations, healthcare professionals, and policymakers to develop the best strategies for prevention and psychological intervention for people at risk.

Schizophrenia is a common disease characterized by psychotic symptoms (e.g., delusion, hallucinations, blunted affect) and disturbances of cognitive function (e.g., memory, abstraction, attention). If not treated properly, patients may experience serious consequences in terms of social function. Much endeavor in several disciplines of medical science has been made to overcome the paucity of effective treatments for unmet needs, including cognitive impairment associated with schizophrenia.This Book, contributed by experts from various regions of the globe, provides up-to-date information to facilitate the development of personal therapeutics for this enigmatic illness. Related Books Schizophrenia Research and Care—Advancements and Challenges Public Health & Healthcare ... 10th Anniversary of Biomedicines—Translational Laboratory and Experimental Medicine for the Sake of Neurological Diseases and Mental Illnesses Biology & Life Sciences ... Recent Advances in Psychopathology in Neurod

Poly(lactic-co-glycolic acid) (PLGA) is one of the most successful polymers used for producing therapeutic devices, such as drug carriers (DC). PLGA is one of the few polymers that the Food and Drug Administration (FDA) has approved for human administration due to its biocompatibility and biodegradability. In recent years, DC produced with PLGA has gained enormous attention for its versatility in transporting different type of drugs, e.g., hydrophilic or hydrophobic small molecules, or macromolecules with a controlled drug release without modifying the physiochemical properties of the drugs. These drug delivery systems have the possibility/potential to modify their surface properties with functional groups, peptides, or other coatings to improve the interactions with biological materials. Furthermore, they present the possibility to be conjugated with specific target molecules to reach specific tissues or cells. They are also used for different therapeutic applications, such as in vac

This Special Issue addresses current challenges in the plant health of horticultural crops, highlighting the role of biocontrol agents as sustainable alternatives to the overuse of chemical pesticides. In a context where pathogens threaten global agricultural productivity, this collection of studies offers innovative approaches. The included articles range from region-specific epidemiological analyses, such as the study of downy mildew in Spanish vineyards, to findings on new diseases, such as the occurrence of Botrytis cinerea on pecan nuts in China. Several studies explore the efficacy of microorganisms such as Trichoderma asperellum and Exiguobacterium acetylicum, in disease control and in plant growth promotion. Viruses such as BCMV and BYMV are investigated in legumes, with the results being used to propose management strategies based on certified seeds and sustainable cultural practices. Other studies highlight biological pest control, such as the use of entomopathogenic nematodes against Pieris brassicae and beneficial bacteria to combat white rot in onion. Finally, a comprehensive review on the use of biocontrol agents in horticulture is presented, addressing genetic, environmental, and application aspects. Research shows that the use of biological agents can reduce reliance on synthetic chemicals, protect biodiversity, and ensure resilient agricultural systems.

Cancer is one of the leading causes of morbidity and mortality worldwide.  The World Cancer Research Fund determined that the diet and nutrition conditions of the individuals are modifiable risk factors in the development of several cancers and a predominant component in the recovery and effectiveness of the treatments. Nutritional intervention is critical, but nutritional support is not widely accessible to all individuals, leading to potential nutritional risk and nutrition wasting. A multidisciplinary approach with targeted nutrition is vital to improve the quality of care in oncology. Cachexia management remains a challenge in clinical practice and malnutrition is accepted as a significant negative predictive and prognostic factor in all cancer patients. The importance of metabolic interactions within the tumours are crucial and the mechanisms by which dietary factors might increase or decrease therapeutic intervention are key factors to unravel the nutrition influences in cellul

There is some talk about an antibiotic Armageddon due to quickly developing resistance towards commercially available antibiotics. For the most part, the classical antibiotic pipeline has dried up, and antibiotic resistance to any new drugs quickly develops. It is here that metal-based antimicrobials can step forward as possible solutions in this antimicrobial resistance era. The biological targets of metal atoms are more diverse, thus making it more difficult for bacteria to develop resistance compared with classical antibiotics. The metal silver has been used since antiquity for wound healing and water purification. At present, it is the most prevalent antimicrobial metal used in healthcare, industry, and consumer products. Silver is being used in the form of ionic salt, colloids, or in specific nanomaterials, and as described in this book, it can be applied as mixtures with other antimicrobials or coating composites. The different formulations are explored for their efficacy agains

This Special Issue focuses on recent advancements in the diagnosis and management of skin cancer, encompassing melanocytic tumors, keratinocyte tumors, soft tissue tumors, sarcomas, and others. With skin cancer incidence rising globally, accurate and early diagnoses, along with novel therapeutics, are crucial public health concerns. In alignment with the shift toward precision medicine and with the goal of enhancing knowledge and contributing to improved diagnostic and management approaches for skin cancer, this issue focuses on both technological advancements in detection and advancements in therapeutic approaches to skin cancers, such as newly discovered therapeutic targets, advanced delivery systems, and novel medical devices.

Bioactive compounds have a range of chemical structures and biological activities. Recently, new advances regarding natural compounds were achieved, leading to their application in several areas related to human therapies. New computational methods that analyze the pharmacological potential of natural products have led to its its conversion into low toxicity molecules. This Special Issue has collected the most recent innovations in scientific research on natural products, together with the application of bioactive compounds in human health. It acts as a reference for academic researchers and health and industry professionals, particularly those working in the fields of medicinal chemistry, toxicology, phytochemistry, and natural product chemistry. Related Books Advances on Applications of Bioactive Natural Compounds Biology & Life Sciences ... Phytochemicals of Natural Products Biology & Life Sciences Biological Activity and Applications of Natural Compounds Biology & Life Sciences

This Special Issue presents a curated collection of articles exploring the transformative role of artificial intelligence (AI) in oral and maxillofacial imaging. The contributions highlight recent advancements in machine learning, radiomics, and deep learning techniques applied to diagnostic tasks involving complex anatomical regions and diverse pathologies. Emphasis is placed on the integration of AI for improving diagnostic accuracy, supporting clinical decision-making, and enabling precision medicine in the fields of radiology and oncology. The papers also discuss technical challenges, validation strategies, and ethical considerations that accompany the clinical implementation of AI technologies. By bringing together original research and comprehensive reviews, this Special Issue offers a valuable resource for clinicians, researchers, and developers interested in the future directions of AI in oral and maxillofacial imaging.

Cancer affects a large proportion of the global population and remains one of the leading causes of death worldwide, ranking second according to the World Health Organization. Despite advances in surgery, chemotherapy, and radiotherapy, major challenges, such as drug resistance, systemic toxicity, and limited tumor selectivity, continue to drive the search for more effective therapies and improved drug delivery strategies. This Special Issue brings together original research and review articles highlighting recent progress in cancer treatment. Contributions cover diverse approaches, including novel small-molecule anticancer agents, epigenetic modulators, nanotechnology-based and combination therapies, externally activated targeted treatments, drug repurposing, and immunotherapy. The collection reflects the multidisciplinary nature of modern oncology, spanning mechanistic insights and translational applications. The Issue also presents emerging experimental platforms and enabling technologies, including 3D in vitro cancer models, organoid-based drug testing, and machine learning-supported preclinical research. Novel therapeutic modalities—such as photothermal and photoimmunotherapy, nanovesicle drug delivery, dual-action treatments, and natural compounds—are also explored. Overall, this collection highlights innovative strategies aimed at improving the efficacy, selectivity, and safety of cancer therapies and advancing more personalized treatment approaches.

This reprint offers a comprehensive overview of the recent progress in the field of functional biomaterials applied to medicine. The collected articles address critical aspects of biocompatibility, the immune response, and material performance in the context of biomedical devices and implants. Special attention is given to interdisciplinary approaches that integrate materials science, biology, and clinical insights to support the safe and effective use of advanced biomaterials. Contributions cover a broad spectrum of topics, including innovations in dental implant materials, nanoparticle-based therapies, and the medical utilization of emerging biomaterials. Together, these studies underscore the challenges and solutions involved in assessing the biological behavior of functional materials and their translation into real-world clinical applications. This collection serves as a valuable resource for professionals and researchers engaged in the designing, testing, and implementation of next-generation medical biomaterials.

Daily clinical practice is introducing new devices and tools that support doctors in achieving a better diagnosis. This Special Issue shows ten application cases where an algorithm or device is proposed to provide better information to doctors and help them to get more data, leading to better diagnosis and treatment prescription. The cases described here show both hardware and software, including the use of recent artificial intelligence and deep learning techniques. Related Books Artificial Intelligence Advances for Medical Computer-Aided Diagnosis Biology & Life Sciences Algorithms for Fault Detection and Diagnosis Computer Science & Mathematics ... Machine Learning and Deep Learning for Healthcare Data Processing and Analyzing Biology & Life Sciences ... Artificial Intelligence (AI) and Machine Learning (ML) in Medical Imaging Informatics towards Diagnostic Decision Making Public Health & Healthcare Biomedical Application of Big Data and Artificial Intelligence Computer Science &

Tumor cells commonly exhibit dependence on a single activated oncogenic pathway or protein to maintain their malignant proliferation and survival, a phenomenon called “oncogene addiction”. According to this concept, protein kinases have been identified as promising molecular targets for cancer therapy. There are several possibilities for targeting these proteins in cancer, including monoclonal antibodies, compounds able to favor the proteolytic degradation of the kinase, small-molecule protein kinase inhibitors (PKIs). Moreover, new anticancer treatments have increasingly been developed focusing on tumor suppressor genes and RNA interference. Despite promising results in cancer treatment with targeted cancer drugs, clinical experience has shown that only a fraction of patients respond to targeted therapies, even if their tumor expresses the altered target. This is known as primary resistance. Otherwise, secondary or acquired resistance to the treatment arises, almost invariably, when

The Special Issue aimed to bring together scientists working in various branches of control theory to discuss manufacturing control problems that include the following: enterprise control and digital ecosystem creation; the development of identification theory and methodology, and related mathematical problems; parameter, nonparametric, and structure identification and expert analysis; problems regarding selection and data analysis; control systems with an identifier; modeling in intelligent systems; simulation procedures and software; digital identification; reinforcement learning; quantum modeling; intelligent model predictive control; predictive cognitive issues; problems with software quality for complex systems; and global network resources for support processes of modeling and control. Related Books Advanced Digital, Modeling and Control Applies into Various Processes Computer Science & Mathematics Data-Driven Intelligent Modeling and Optimization Algorithms for Industrial Pro

Obesity is a pressing public health issue, closely linked to metabolic comorbidities including type 2 diabetes, dyslipidemia, liver diseases, and cardiovascular diseases. Excessive or inappropriate nutrient intake triggers chronic inflammation, disrupts metabolic pathways, and leads to insulin resistance and systemic dysfunction. Nutritional interventions are increasingly recognized as effective tools for managing obesity and related disorders. This Special Issue of Biomolecules explores the molecular roles of macro- and micro-nutrients, alongside current dietary guidelines. We delve into the key metabolic pathways and mechanisms by which nutrients influence obesity and metabolic diseases, including the role of the gut microbiota in modulating metabolic responses to nutrition, offering insights into how diet and microbial interactions shape human metabolic health. This Reprint aims to advance understanding of the pathogenesis of obesity, type 2 diabetes, non-alcoholic liver disease, cardiometabolic disorders, and malnutrition. We collected original research and reviews on innovative nutritional strategies, molecular mechanisms, and preclinical discoveries.

Science has tremendously advanced our understanding of the pathophysiology of chronic pain. Breakthrough findings include functional and structural brain changes, neuro-inflammation, sensory changes, immune alterations, psychological problems, neurocognitive disorders, stress intolerance, sleep impairments, and (epi)genetic changes found in patients with chronic pain. This Journal of Clinical Medicine Boutique Special Issue focuses on the broad field of the biology of chronic pain in humans. It includes invited state-of-the-art papers addressing key biological processes in patients with chronic pain and original research reports. The state-of-the-art papers were written by leading experts and key opinion leaders in the field. This Special Issue contributes to an exciting area of tremendous advancements and breakthrough research. Related Books Clinical Management of Chronic Pain Medicine & Pharmacology Clinical Diagnosis and Treatment of Chronic Pain Medicine & Pharmacology Chronic P

I am proud to present this Special Issue, “Emergency Medicine: Clinical Advances and Challenges in Diagnosis and Treatment,” dedicated to new advances and challenges in emergency medicine. In an ever-evolving world, emergency medicine remains a benchmark for knowledge and prompt action in critical situations. This reprint is a tribute to the medical achievements, dedication, and profound compassion of those who dedicate their lives to saving others. This Special Issue describes the clinical advances and complex challenges in diagnosis and treatment. Each article is designed to give readers a deeper understanding of the latest findings and solutions in this dynamic field. In closing, I hope you can join this journey of knowledge and contribute, each uniquely, to the evolution and improvement of this fascinating field, emergency medicine. I express my gratitude to all of the authors for their valuable contributions and efforts in making this reprint a reality and to our readers for joi

Endometriosis is defined as the presence of endometrial-like endometrial cells, glands, and stroma outside the uterus, causing a wide range of symptoms and signs, including acute and chronic pelvic pain and infertility. Endometriosis affects approximately 10\% of women of reproductive age, and up to 50\% of infertile women. The etiopathogenesis of endometriosis still remains controversial: immune, hormonal, genetic, and epigenetic factors may be all involved, and several theories have been proposed to explain it.One of the main problems for the management of endometriosis is the significant diagnostic delay: to date, several biomarkers are currently being tested in order to provide a reliable non-invasive diagnosis in case of symptoms and signs suspicious for endometriosis.In addition, ultrasound techniques and magnetic resonance imaging are evolving rapidly, allowing for better accuracy, even with the use of artificial intelligence. Finally, new potential histological makers are helpi

Alzheimer’s disease (AD) represents the most common form of dementia in the elderly population worldwide. AD is characterized by progressive neurodegeneration that leads to a gradual deterioration of memory and other cognitive functions. Given the global prevalence and impact of AD, there is a critical need to establish biomarkers that can be used to detect AD in individuals before the onset of clinical signs and provide mitigating therapeutics. The aim of this Special Issue is to discuss the current knowledge as well as future perspectives on the role of biomarkers in the screening, diagnosis, treatment and follow-up of AD. Related Books Biomarkers in Neurodegenerative Diseases Medicine & Pharmacology Biochemical Biomarkers and Neurodegenerative Diseases Biology & Life Sciences Commemorative Issue Celebrating the 20th Anniversary of the Alzheimer’s Foundation of America: Understanding and Treating Alzheimer’s Disease Medicine & Pharmacology Amyloid-β Biology & Life Sciences Molecul

The Special Issue “Body Image, Nutrition, and Mental Health” examines and illuminates the complex relationships among body image, nutrition, and mental health. It covers the psychological and social risk factors of body image disturbances and associated disorders, biological aspects of appetite regulation and the metabolic syndrome, and therapeutic approaches for eating and weight disorders and their health consequences. Related Books Eating and Mental Health Disorders Public Health & Healthcare Body Image and Nutritional Status Among Adolescents and Adults Biology & Life Sciences Nutrition and Fitness Public Health & Healthcare ... Public Health, Nutritional Behavior and Nutritional Status Public Health & Healthcare Recent Advances in Nutritional Psychiatry Medicine & Pharmacology The recommendations have been generated using an AI system. About: About MDPI Books Advisory Board Legal Information: MDPI Privacy Policy Terms and Conditions Terms of Use Accessibility Sales: Orde