Perpustakaan Digital

Food products are becoming increasingly affected by the use of antibiotics, as the transfer of residual veterinary drugs, antibiotic-resistant bacteria (ARB), and antimicrobial resistance (AMR) and its genes (ARGs) occurs through unexplained mechanisms, representing a public health threat. As part of the framework proposed by One Health, it is essential to include information on animal and food chain pathogens in AMR surveillance programs, since human and animal health are interconnected. Therefore, this Special Issue will pay specific attention to human, animal, plant, food, and environment interfaces, and will try to explore intervention strategies against foodborne pathogens. Furthermore, it will characterize the variation in the composition of a healthy human gut microbiome in correlation with antibiotic usage and yoghurt consumption. The Special Issue focus on intervention strategies and food safety in light of antibiotic usage in animal and plants, and discuss ARB and ARG in fu

In Canada, survival from breast cancer has steadily increased since 1989, and breast cancer mortality has decreased by 48\%. While 82\% of women with breast cancer are diagnosed at stage 1 or 2, there are still 18\% who present at a late stage and 25\% who develop metastatic disease. Improved survival has been achieved through early diagnosis of breast cancer with screening, allowing for more effective and targeted treatments. This reprint summarizes the latest evidence on the early detection of breast cancer and highlights areas where this may be improved. Related Books Treatment Strategies and Survival Outcomes in Breast Cancer Medicine & Pharmacology Innovations in the Integrated Management of Breast Cancer Medicine & Pharmacology Breast Cancer—Therapeutic Challenges, Research Strategies and Novel Diagnostics Medicine & Pharmacology Breast Cancer: A Multi-Disciplinary Approach from Imaging to Therapy Medicine & Pharmacology Advances in Breast Cancer Research and Treatment Biology & L

This Special Issue of the Journal of Clinical Medicine is dedicated to polycystic ovary syndrome (PCOS). It includes 12 interesting papers from all around the world that contribute important new information regarding the pathogenesis, clinical evaluation, and treatment of this very common disorder that affects about 10\% of all women during their adult life. The first paper presents an evolutionary model of PCOS that has profound consequences on the methods of preventing and treating this syndrome. Other papers describe problems related to differential diagnosis from hypothalamic amenorrhea and the use of questionnaires for detecting alterations in the quality of life of these women. Two papers are dedicated to sexual problems that may arise in these patients. Many papers analyze the actual treatment of PCOS, from the promotion of physical activity to the use of oral versus intravaginal contraceptives. Articles also investigate how to optimize the clomiphene induction of ovulation or

This Reprint reports on cutting-edge research and advances in the field of dental biomaterials. Leading experts share their findings and research results on the development, characterization and application of advanced biomaterials in dentistry. They report on novel biocompatible, durable and efficient dental materials; their mechanical properties; and new fabrication techniques. Topics of interest include, but are not limited to, dental coatings, composites, ceramics, adhesives, dental implants, tissue engineering approaches and bioactive materials. Using computational modeling and simulations, valuable information is provided on promising advances in the development of dental biomaterials.

The past decade has seen immunotherapy rise to the forefront of cancer treatment. This Special Issue of Cancers aims to elaborate on the latest developments, cutting-edge technologies, and prospects in cancer immunology and immunotherapy. Seventeen exceptional studies, including original contributions and review articles, written by international scientists and physicians, primarily concerning the fields of tumor biology, cancer immunology, therapeutics, and drug development, comprise the main body of this Special Issue. Related Books Tumor Immunology and Immunotherapy Resistance Medicine & Pharmacology The Immunology and Biology of Brain Tumors Medicine & Pharmacology Challenges and Opportunities for Effective Cancer Immunotherapies Medicine & Pharmacology Immunotherapy, Tumor Microenvironment and Survival Signaling Medicine & Pharmacology Cell Therapy, Bispecific Antibodies and other Immunotherapies Against Cancer Medicine & Pharmacology The recommendations have been generated us

Dietary habits differ from person to person and usually are determined by cultural habits and traditions that determine lifestyles linked to the socio-demographic characteristics associated with ethnicity. It is known that dietary habits, lifestyle and socio-demographic factors impact human health. Eating disorders, increasing consumption of less-healthy foods, lack of exercise, genetic predisposition, along with other factors, increase risk of diseases such as dyslipidemia, diabetes, obesity, cardiovascular disease, hypertension, and various mental disorders. This reprint entitled “Dietary Influence on Nutritional Epidemiology, Public Health and Our Lifestyle”, addresses the associations between some dietary patterns, lifestyle and socio-demographic factors, analyzed either separately or in combination, with the risk and management of cardiovascular diseases and mental health problems, such as depression and dementia. This reprint includes nine original articles and one systematic

Recently, many kinds of foods and food-derived nutrients have been reported to show health-beneficial effects. In particular, some foods and food-derived nutrients have shown anti-aging effects on several organs and tissues, such as brain, muscle, skin, intestine, and so on. In some kinds of foods, the molecular basis of their functionalities (e.g., anti-brain aging, anti-sarcopenia, and anti-skin aging) and inter-tissue networks activated by these foods mediated by exosomes, cytokines, and immune cells have been clarified in detail. Related Books Nutrition, Diet and Healthy Aging Biology & Life Sciences Antioxidant and Anti-Aging Action of Plant Polyphenols Medicine & Pharmacology Aging, Natural Bioactive Compounds and Non-communicable Chronic-Degenerative Diseases Public Health & Healthcare Optimising Nutrition to Alleviate Age-Associated Functional Decline Biology & Life Sciences Dietary Strategies for Prevention of Geriatric Diseases and Exploring the Mechanism of Aging Biology

This collection of papers describes recent advances in drug delivery systems, with a focus on nanocarriers, controlled release mechanisms, and their biomedical applications. The selected contributions explore a wide range of strategies for improving the therapeutic efficacy and targeting of pharmaceutical compounds through innovative formulation approaches. Strong emphasis is placed on the development of transdermal patches, hydrogels, liposome-based carriers, nanoemulsions, and functionalized nanomaterials, all of which have been designed to optimize drug release profiles and enhance pharmacokinetics. Antibacterial and anticancer applications are particularly well represented, reflecting the current challenges in both infectious disease treatment and oncology. By integrating engineering, pharmaceutical science, and medical research, this collection offers a comprehensive overview of modern approaches to drug delivery and their potential for clinical translation. Furthermore, these works highlight the growing relevance of biocompatible and sustainable materials, along with mathematical modeling for release kinetics, in shaping the future of therapeutic technologies.

Nutrition, often along with physical activity, is by now acknowledged as a cornerstone in the prevention and even more so the treatment of many diseases. Indeed, food and nutritional intake nowadays are often thought to be the main source of wellbeing sometimes over- but also underestimating the impact of nutritional intake, dietary pattern and food-derived natural compounds in their impact on human health. In this Special Issue entitled `Clinical Nutrition: Recent Advances and Remaining Challenges´ a broad overview and summary on recent findings in various fields of clinical nutrition with special focus on chronic and degenerative diseases like metabolic diseases, cancers, neurodegenerative diseases, inflammatory bowel diseases, sarcopenia but also malnutrition in elderly, infants and children is provided. Nutrition, often along with physical activity, is by now acknowledged as a cornerstone in the prevention and even more so the treatment of many diseases. Indeed, food and nutriti

Climate change poses a serious challenge to our health and wellbeing. The increasing frequency of extreme weather events such as floods, droughts, and heatwaves, and the direct impacts of changes in temperature have direct impacts on health. At the same time, broader environmental change affects infectious disease risk, air pollution, and other forms of exposure. The different ways in which climate change will affect health are complex, interactive, and different communities are disproportionately affected. International actions such as the Paris Agreement and the Sustainable Development Goals recognise the future risks to society and acknowledge that we are already committed to a certain level of climate change. Future adaptation measures therefore need careful assessment and implementation for us to be able to minimise the potential risks from climate change and, at the same time, maximise the potential health benefits of a cleaner, greener world. This Special Issue comprises origin

Marine Drugs is glad to announce its first Special Issue book on “ion channels” related research: Under the great stewardship of the Guest Editor, Dr. Jean-Marc Sabatier, four advanced research articles and three comprehensive review papers were collected in the Special Issue “Ion Channels as Marine Drug Targets”. Join us to explore the advanced research outcomes in this field: α-Conotoxin RgIA and a potent analog, RgIA4, in treatment of pain; botulinum toxin-chitosan nanoparticles in treatment of atrial fibrillation; 27-amino acid (aa)-long δ-conotoxin TxVIA that modulates mammalian CaV3.x; first venomics study of Conus tulipa venom; review on marine toxins targeting Kv1 channels; review on synthetic approaches to zetekitoxin AB; and review on marine natural products and drug resistance in latent tuberculosis. The second edition of this Special Issue is open for submissions, we look forward to your contribution. Related Books Drugs from Marine Sources Biology & Life Sciences ... Ion

Genomics technologies revolutionised biomedicine research, but the genome alone is not sufficient to capture biological complexity. Postgenomic methods, typically based on mass spectrometry, comprise the analysis of metabolites, lipids, and proteins and are an essential complement to genomics and transcriptomics. Multidimensional omics is becoming established to provide accurate and comprehensive state descriptions. This book covers the latest methodological developments for, and applications of integrative multi-omics in biomedical research. Related Books Multi-Omics for the Understanding of Brain Diseases Biology & Life Sciences ... Application of Multi-Omics Analysis in Cancer Diagnosis, Treatment and Prognosis Biology & Life Sciences Omics Technologies in Food Science Biology & Life Sciences Systems Analytics and Integration of Big Omics Data Biology & Life Sciences ... Omics Approaches for Crop Improvement Biology & Life Sciences The recommendations have been generated using an

The wide spread of COVID-19 has had significant and negative effects on human well-being, but it has also had a negative impact on many important diseases. It has necessitated a major reorganisation of emergency care facilities to accommodate the additional workload anticipated with the rapid surge in critically ill patients with COVID-19. Previous reports have demonstrated a reduction in admissions for different conditions such as acute coronary syndrome or decreased use of coronary procedures in various countries affected by the COVID-19 pandemic, leading to an increase in out-of-hospital deaths and long-term complications of myocardial infarction and missed opportunities to offer secondary prevention treatment for patients with coronary heart disease.In this context, we do not know what impacts these events may have had on psychology and sexuality. In fact, the global pandemic of COVID-19 has significantly impacted people’s sexual desire and behaviours.Besides these events, the da

Over the last few decades, nanomedicine has become a hot topic in formulation science regarding selectively delivering drugs to target tissues. Nanomedicines can modify drug release and encapsulate poorly soluble drugs, allowing for a selective targeting and minimizing adverse effects. This is of key importance in antitumoral and anti-infectious therapies, in which undesired drug release can lead to severe damage to healthy tissues. Moreover, they protect drugs from degradation, allowing for the the delivery of RNA. This reprint encompasses works describing the design, development and characterization of lipid nanomedicines, dendrimers and virus nanoparticles among others, as well as the evaluation of their toxicity and their anticancer and antifungal efficacy. Moreover, it analyzes the quality assessment of nanomedicines under clinical investigation. Related Books Engineering and Characterisation of Novel Nanomedicine Formulations, 2nd Edition Biology & Life Sciences ... Nanomedici

Biomaterials can be used as implantable devices or drug delivery platforms, and have significant impacts on a patient’s quality of life. Indeed, every year, a substantial number of new biomaterials and scaffolding systems are engineered and introduced in the biomedical field, with increased health benefits. However, their long-term use can be threatened by the adhesion and proliferation of microorganisms or by the formation of fibrosis. Pathogenic microorganisms may cause local infections and lead to implant failures. Additionally, they can hinder the delivery of therapeutic molecules by specialized carriers, rendering them ineffective. Many alternatives have been proposed over the years to prevent such events, including the use of antiseptics and antibiotics, or physical modifications of the biomaterial surface with the incorporation of biomolecules. From specialized polymers and functional groups to silver and, more recently, antimicrobial peptides and natural extracts, different f

This Special Issue summarizes the latest research findings on identifying natural products targeting multiple pathways and body functions that can successfully treat multifactorial diseases. Research articles presented in this issue may be of great interest to pharmacologists, pharmacists, and physicians interested in the complementary treatment of disease.

This Reprint presents a focused collection of recent research articles and reviews on small molecule modulators targeting emerging therapeutic pathways. The contributions highlight current advances in medicinal chemistry and chemical biology, integrating molecular design, synthesis, and biological evaluation to address complex disease mechanisms. Several studies report small molecules that modulate key signaling pathways, overcome therapeutic resistance, and promote regulated cell death, particularly in cancer models. Structural and mechanistic investigations provide molecular-level insights into target engagement, including enzyme and proteasome inhibition, supporting structure-guided drug design. Other contributions combine biophysical methods, computational modeling, and functional assays to clarify mechanisms of action and guide optimization. The Reprint also includes studies on immune and inflammatory modulation, studies on metabolic and lipid signaling regulation, and updated reviews on naturally derived inhibitors and hypoxia-responsive compounds. Together, these works emphasize multidisciplinary approaches and biological relevance in small molecule research. Overall, this Reprint reflects current trends in pathway-oriented therapeutic development and serves as a valuable reference for researchers in drug discovery, chemical biology, and pharmacological sciences.

Global cancer incidence and death are expected to increase in the next decades. Inappropriate therapeutic regimens and tumor recurrence due to the development of drug resistance are two major clinical challenges impacting poor patient outcomes, which is critical to the discovery and development of new anticancer drugs. Over the last few decades, the marine environment has proved to be a key source of molecules with potent anticancer properties. The Special Issue, “Marine Natural Products as Anticancer Agents 2.0”, gathered eleven publications, including two reviews and nine research articles, about the anticancer activities of marine natural and/or derived products on in vitro 2D and 3D cellular models, and/or in vivo models of colorectal, breast, lung, myeloma, liver, leukemia, and melanoma cancers. Altogether, the eleven scientific papers published in this Special Issue provide an exciting overview of marine natural products as potential anticancer agents. Related Books Marine Nat

Biofilms are multicellular sessile microbial communities embedded in hydrated extracellular polymeric matrices. Their formation is common in microbial life in most environments, whereas those formed on food-processing surfaces are of considerable interest in the context of food hygiene. Biofilm cells express properties that are distinct from planktonic ones, in particular, due to their notorious resistance to antimicrobial agents. Thus, a special feature of biofilms is that once they have developed, they are hard to eradicate, even when careful sanitization procedures are regularly applied. A large amount of ongoing research has investigated how and why surface-attached microbial communities develop such resistance, and several mechanisms can be acknowledged, such as heterogeneous metabolic activity, cell adaptive responses, diffusion limitations, genetic and functional diversification, and microbial interactions. The articles contained in this Special Issue deal with biofilms of some

"Alcohol-Induced Oxidative Stress in Health and Disease" explores the key role of oxidative stress in alcohol-related health conditions, offering a comprehensive investigation of its molecular mechanisms, clinical implications, and potential therapeutic strategies. This collection, curated from the Antioxidants (MDPI) Special Issue, brings together leading research on how alcohol consumption disrupts redox balance, contributes to tissue damage, and influences diseases such as liver and cardiovascular disorders and neurodegeneration.Featuring contributions from experts in biomedical research, toxicology, and clinical medicine, this reprint provides important insights into antioxidant defense mechanisms and emerging interventions. It could be an essential tool for researchers, clinicians, and public health professionals seeking to understand and mitigate the health impacts of alcohol-induced oxidative stress.Whether you are a scientist investigating the biochemical pathways of oxidative damage or a healthcare professional exploring new treatment approaches, this book might advance knowledge and improve health outcomes in alcohol-related diseases.

Introducing “A Feasible Approach for Natural Products to Treatment of Diseases”–an exploration of the therapeutic potential locked within nature’s abundant offerings. This comprehensive reprint delves into the fascinating realm of natural products, uncovering their inherent properties, mechanisms of action, and potential roles in effective disease management. Through extensive scientific research and reviews, the authors shed light on the immense potential of natural products as a viable approach to enhancing health and combating diseases. This reprint presents a diverse and multidimensional exploration, bridging the gap between traditional wisdom and contemporary scientific understanding and offering new avenues for healthcare professionals, researchers, and enthusiasts to harness the power of nature’s remarkable resources. As a catalyst for unlocking the healing potential of natural products, this reprint inspires further investigation and innovation, and drives us towards a future

Changes in lifestyle and a shift from a traditional to an industrialized/westernized diet has drastically increased the rates of diet-related chronic disease. This has led to an unprecedented explosion in the prevalence of obesity and being overweight, cancers, and chronic and metabolic diseases. The physiological mechanism of action of nutritional compounds is closely associated with their ability to recognize and modulate specific cellular enzymes or to affect the cell redox state. The identification of these targets is essential to recognize the mechanisms of action of nutritional compounds and their direct or indirect effects on cellular processes and functions in physiological and pathological conditions. Related Books Metabolic Features and Nutritional Interventions in Chronic Diseases Biology & Life Sciences ... Nutrition, Metabolism, and Obesity Biology & Life Sciences Diet and Nutrition Biology & Life Sciences Nutritional Support for Chronic Disease Biology & Life Sciences

ADP-ribosylation was discovered over 60 years ago, and much of the research focused on bacterial toxins that employed ADP-ribosylation to kill host cells. However, in the last 20 years, the field has identified many cases where host-mediated ADP-ribosylation can either promote or repress pathogenic infections. It is clear that ADP-ribosylation is a key component of the innate immune response in eukaryotes and bacteria, and many of the mechanistic details of how ADP-ribosylation impacts pathogens have yet to be uncovered. In this Special Issue, we have focused on publishing unique reviews and primary research on the topics of pathogens and ADP-ribosylation. We hope that you will enjoy this collection. Related Books Biological Activities of Ribosome-Inactivating Proteins Biology & Life Sciences ... Ribosome Inactivating Toxins Medicine & Pharmacology Natural Products and Their Modifications as Agents Used in the Fight against Pathogens Medicine & Pharmacology Toxin and Immunotoxin Bas

This book focuses on the proposition of a paradigm shift to enable stratification of the highly heterogeneous autism spectrum disorders, by borrowing from and adapting the precision medicine model. A compilation of 9 rigorously peer-reviewed manuscripts offers new approaches to automatically stratify autism-related genes into different neuropsychiatric and associated neurological disorders and, accordingly, repurpose existing therapies and support systems for each thus uncovered phenotypic subtype. Methods for telemedicine are introduced to scale diagnostics and brought to underrepresented communities, thus diversifying the pool of participants in research and treatments. Biosensor data and methods are introduced to accompany genomics subtyping with precision phenotyping. Importantly, an in-depth review offering a paradigm shift for early detection and treatments of autism is presented through stages of neurodevelopment spanning from the womb to infancy and beyond, across the human l