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Cannabis has a history of medical use dating back millennia; however, the use of cannabis for medicinal purposes fell out of favor in the middle of the last century. There is currently a renewed interest in the potential medicinal value of this plant, as well as individual compounds produced by Cannabis (as well as synthetic analogs). Currently, nearly 50 countries permit the medical use of cannabis, and over a dozen other countries have legalized cannabis-based products (CBD, Sativex, Dronabinol, etc.) for medical use. While there exists a plethora of anecdotal reports indicating that cannabis can treat a variety of diseases, there is a limited amount of strong, evidence-based scientific data to support these claims.  This Special Edition of Biomedicines, “Therapeutic Potential for Cannabis and Cannabinoids”, was dedicated to providing evidence for the medicinal value of cannabis to treat human illness and disease. Topics included, but were not limited to, preclinical animal models

Inorganic biomaterials encompass a wide range of materials, including metals, polymers, ceramics, and composites, and play a pivotal role in chemistry, materials science, biology, medicine, and biomedical engineering. With tunable intrinsic properties (e.g., shape, size, aspect ratio, surface-to-volume ratio, topography, electrostatic interactions) and versatile functionality, inorganic nanoparticles and biomaterials are highly sought after in molecular imaging and clinical therapy. The applications extend across regenerative medicine, tumor and atherosclerosis imaging, tissue engineering, drug delivery, orthopedic implants, photothermal therapy, and the design of medical devices. In addition, inorganic biomaterials, nanoparticles, and hybrid assemblies can function as scaffolds for immobilizing biomolecules, enabling the development of advanced materials tailored for specific biological applications. The Special Issue highlighted 10 original research papers and a review article on the structural characterization, biophysical and biochemical properties, and biocompatibility of inorganic biomaterials, as well as their wide-ranging applications. Topics included imaging, therapeutic drug delivery in neutron capture therapy, optical sensing, SARS-Cov2 diagnosis, tumor therapy, tissue engineering, and regenerative medicine. The overarching objective was to showcase recent advances in inorganic biomaterials and nanoparticles, spanning all stages from design to application.

The oral cavity is the port of entry to the gastrointestinal and respiratory tracts, characterized by the juxtaposition of soft and hard tissues. It is continuously subject to challenges by the external environment, such as foreign antigens or material.Oral microbial communities are now seen as the fundamental etiological agent in oral diseases through their interface with host inflammatory responses. Thus, it is essential to understand the molecular mechanisms and pathogenicity of oral diseases from immunological and microbiological perspectives. Oral medicine concerns with the diagnosis and management of oral diseases, including oral mucosal disease, oral cancer, salivary gland disorders, temporomandibular disorders and oral manifestations of systemic and infectious diseases. This Special Issue aims to outline all areas of oral medicine in order to depict various oral diseases from immunological and microbiological perspectives. Related Books Oral Inflammations and Systemic Diseas

Radiopharmaceuticals are used in the diagnosis and treatment of various diseases, especially cancer. In general, radiopharmaceuticals are either salts of radionuclides or radionuclides bound to biologically active molecules, drugs, or cells. Tremendous progress has been made in discovering, developing, and commercializing numerous radiopharmaceuticals for the imaging and therapy of cancer. Significant research is ongoing in academia and the pharmaceutical industry to develop more novel radiolabeled compounds as potential radiopharmaceuticals for unmet needs. This Special Issue aims to focus on all aspects of the design, characterization, evaluation, and development of novel radiolabeled compounds for the diagnosis and treatment of cancer and the application of new radiochemistry and methodologies for the development of novel radiolabeled compounds. Outstanding contributions presented in this Special Issue will significantly add to the field of radiopharmaceuticals. Related Books Pre

The continuous evolution of preventive and therapeutic strategies aims to enhance oral health outcomes. Novel approaches are being developed to prevent and treat prevalent oral diseases like dental caries, periodontitis, and oral cancer. Researchers are also exploring the potential of biomaterials in regenerative dentistry, such as promoting bone growth and repairing damaged oral tissues.The ongoing research and development in dental materials and biomaterials holds great promise for improving oral health outcomes. However, it is imperative to maintain a sustained focus on research to fully leverage their potential and effectively address the existing gaps in dental care.In the special issue titled "Dental Biomaterials: From Fundamental Principles to Clinical Applications," significant findings have emerged from a variety of sources, including in vitro experiments and clinical trials. These insights have deepened our understanding of oral disease biology, resulting in the development

Environmental exposure to metallic neurotoxicants is a matter of growing concern since it may have very significant consequences for human health, from impairing neurodevelopment in children to the neurodegeneration processes involved in aging. The scientific community will face many challenges in identifying and preventing the adverse effects of environmental metal exposure on brain health. This collection of articles provides an overview of current work in the field of neurotoxicology of metal contaminants, from the identification of emerging toxic compounds, to the assessment of environmental exposures and associated risks, through the description of the molecular mechanisms involved in neurotoxicity. Related Books Mechanisms of Neurotoxicity Biology & Life Sciences Environmental Toxicology and Human Health Biology & Life Sciences Toxic Metals, Chronic Diseases and Related Cancers Biology & Life Sciences ... Developmental Exposure to Environmental Contaminants Biology & Life Sci

Metal Nanoparticles for Cancer Therapy provides an update on the current state-of-the-art trends in multifunctional metal nanoparticles for cancer therapy. The contributions received in this collection further strengthen the metal-based nanoparticles for multimodel imaging-guided cancer therapy, illustrating the various methods possible and unveiling what the future may bring. This Special Issue aims to share recent progress and trends in this field. It is an essential resource for researchers, academics, and professionals interested in the potential of metal nanoparticles for cancer therapy. Related Books Applications of Nanomaterials in Biomedical Imaging and Cancer Therapy Biology & Life Sciences ... Magnetic Nanomaterials for Hyperthermia-Based Therapy, Imaging, and Drug Delivery Medicine & Pharmacology Application of Nanomaterials in Biomedical Imaging and Cancer Therapy Biology & Life Sciences ... Metal and Metal Oxide Nanoparticles: Design, Characterization, and Biomedical Ap

Biopharmaceutical and pharmaceutical manufacturing are strongly influenced by the process analytical technology initiative (PAT) and quality by design (QbD) methodologies, which are designed to enhance the understanding of more integrated processes. The major aim of this effort can be summarized as developing a mechanistic understanding of a wide range of process steps, including the development of technologies to perform online measurements and real-time control and optimization. Furthermore, minimization of the number of empirical experiments and the model-assisted exploration of the process design space are targeted. Even if tremendous progress has been achieved so far, there is still work to be carried out in order to realize the full potential of the process systems engineering toolbox. Within this reprint, an overview of cutting-edge developments of process systems engineering for biopharmaceutical and pharmaceutical manufacturing processes is given, including model-based proce

This Special Issue delves into the intricate world of miRNAs as modulators of gene expression regulation. These small non-coding RNAs are at the heart of post-transcriptional modulation of gene activity, affecting a myriad of biological processes. The curated selection of articles within this issue offers insights into the roles of miRNAs in health and disease, emphasizing their potential value as therapeutic targets and biomarkers. Featuring original research and in depth-reviews, this Special Issue covers recent miRNA advancements, detailing their regulatory networks and action mechanisms. It highlights new miRNA-linked therapeutic targets and circulating miRNAs as cell-to-cell communication intermediaries. The issue also examines extracellular miRNAs (ex-miRNAs) and their functions, highlighting their presence in biological fluids and their potential utility in clinical diagnostics and disease monitoring. Challenges in miRNA quantification and technological advances for precise me

Many of the most common diseases are influenced by a combination of multiple factors, which include environmental effectors as well as genetic and epigenetic variations. Therefore, these diseases are grouped under the term “complex” diseases because, from the point of view of genetics, they cannot be explained by simple Mendelian inheritance. The aim of this special issue was to identify genetic and epigenetic factors involved in such diseases in order to improve not only the knowledge of risk factors for those diseases, which could be of help for prevention, but also the understanding and characterization of each disease and to optimize and personalize the treatment. Related Books Study on Genotypes and Phenotypes of Neurodegenerative Diseases Biology & Life Sciences Genetic, Epigenetic, Environmental, and Pharmacological Models for Neuroscience, Neurologic Diseases, and Psychiatric Disorders: Advancement in Bench-to-Bedside Translational Research Biology & Life Sciences ... Gene P

Polypharmacy is a necessary and important aspect of drug treatment; however, it becomes a challenge when the medication risks outweigh the benefits for an individual patient. Drug–drug interactions and the introduction of prescribing cascades are common features of polypharmacy, which can lead to ineffectiveness and increased risk of adverse drug reactions (ADR). Genes encoding CYP450 isozymes and other drug-related biomarkers have attracted considerable attention as targets for pharmacogenetic (PGx) testing due to their impact on drug metabolism and response. This Special Issue is devoted to explore the status and initiatives taken to circumvent ineffectiveness and to improve medication safety for polypharmacy patients. Specific areas include drug–drug interactions and consequences thereof in therapeutic management, including PK- and PD-profiling; the application of PGx-based guidance and/or decision tools for drug–gene and drug–drug gene interactions; medication reviews; developmen

This Special Issue is intended to lay the foundation of AI applications focusing on oral health, including general dentistry, periodontology, implantology, oral surgery, oral radiology, orthodontics, and prosthodontics, among others. Related Books Advancements in Artificial Intelligence for Dentomaxillofacial Radiology Medicine & Pharmacology Advances in AI for Health and Medical Applications Public Health & Healthcare ... Artificial Intelligence in Public Health Public Health & Healthcare Artificial Intelligence in Healthcare: Current State and Future Perspectives Public Health & Healthcare Big Data in Dental Research and Oral Healthcare Public Health & Healthcare The recommendations have been generated using an AI system. About: About MDPI Books Advisory Board Legal Information: MDPI Privacy Policy Terms and Conditions Terms of Use Accessibility Sales: Order and Delivery Indexing and Distribution Further Information: Book Series Reprints Book/Chapter Processing Charges Pa

As Guest Editor, I have the pleasure of sharing a Special Issue of Cancers entitled “Novel Biomarkers in Non-Small Cell Lung Cancer (NSCLC)”. This collection includes 10 original articles written by internationally recognized experts in this field. Recent progress in molecular characterization, in addition to a better understanding of the tumor immune context, has been dramatically changing the course of NSCLC patient care. At the same time, the advent of targeted therapies and immunotherapies has been driven by the expanding number of biomarkers that help predict sensitivity to these novel agents. In fact, identifying patients that are most likely to benefit from targeted therapy or immunotherapy is essential in order to optimize treatment outcomes while minimizing the risks of overtreatment or undertreatment. For these reasons, currently, all patients with advanced NSCLC require not only accurate staging but also comprehensive molecular profiling, including an assessment of several biomarkers. This Special Issue offers an overview concerning the latest advancements in NSCLC biomarker research, with a focus on technologies that are needed for their detection and use in clinical practice.

Medicinal plants or medicinal herbs have been identified and used since ancient times to improve the sensory characteristics of food. The main compounds found in plants correspond to four major biochemical classes: Polyphenols, terpenes, glycosides and alkaloids. Plants synthesize these compounds for a variety of purposes, including protection of the plant against fungi and bacteria, defense against insects and attraction of pollinators and dispersal agents to favor the dispersion of seeds and pollens. Related Books Medicinal, Aromatic, Spice Plants Biology & Life Sciences Morphology, Palynology and Phytochemicals of Medicinal Plants Biology & Life Sciences Natural Compounds in Plant-Based Food Biology & Life Sciences Plant Extracts Medicine & Pharmacology Plant Extracts as Functional Food Ingredients Biology & Life Sciences The recommendations have been generated using an AI system. About: About MDPI Books Advisory Board Legal Information: MDPI Privacy Policy Terms and Condition

The development and deployment of safe, effective, affordable, and accessible vaccines are essential for reducing transmission and disease severity. A central component of vaccine evaluation and immune protection against SARS-CoV-2 is the measurement of neutralizing antibodies, which serve as key indicators of antiviral immune activity. Accordingly, there is an urgent need for standardized, reliable, and reproducible in vitro potency assays to assess antiviral products throughout preclinical and clinical development. Neutralizing antibody assays are critical not only for evaluating vaccine efficacy but also for characterizing immune responses in COVID-19 patients, asymptomatic individuals, and vaccinated populations. However, current SARS-CoV-2 neutralization assays—including live virus, recombinant virus, pseudotyped virus, and competition-based assays—exhibit substantial methodological diversity. Differences in protocols, reagents, and result interpretation across laboratories have led to significant variability, limiting comparability between studies and vaccines and hindering the establishment of robust correlates of protection. This reprint provides a systematic and up-to-date overview of advances in SARS-CoV-2 neutralization assay development and vaccine evaluation. By summarizing methodological progress and remaining challenges, it aims to serve as a reference for researchers, clinicians, regulatory scientists, and public health professionals involved in COVID-19 research and response.

This Special Issue of Life, collected and presented data on state-of-the-art innovations in this field. The study by Słowińska et al. focused on the clinical, dermoscopic and histological characteristics of patients with melanoma. Kolahdooz et al. investigated how niosomal curcumin suppresses the IL17–IL23 immunopathogenic axis in the skin lesions of patients with psoriasis. Giuglea et al. analyzed the properties of basal cell carcinoma. Mihulecea et al. concentrated their research on the many roles of dermoscopy in melanoma detection. Fulga et al. studied pharyngeal–esophageal malignancies in patients with dermatologic paraneoplastic syndrome. The original article by Kluger evaluated annular erythemas and purpuras in dermatology. Mihulecea et al. demonstrated and assessed the key factors in melanomagenesis. Nicolescu explored and inspected the psoriasis management challenges regarding difficult-to-treat areas in relation to therapeutic decision and effectiveness. Focused on atopic d

Electrospinning can be used to prepare nanofibrous membranes from diverse polymers. The large surface-to-volume ratio makes them suitable for diverse fields of applications, from filters to catalysts to tissue engineering.Here, we search for the latest developments dealing with nanofiber mats for biomedicine. From wound healing to slow release, and from tissue engineering to stem cell differentiation, nanofibrous membranes can be found in a broad range of biomedical applications. For these utilizations, their chemical as well as physical properties are important, such as hydrophobicity, fiber morphology, membrane porosity, mechanical strength, etc. This Special Issue focuses on nanofibrous membranes for biomedical applications, measuring and optimizing the correlated membrane properties. It covers the full range from basic research on new materials and producing novel electrospun structure to drug release to cell growth on nanofiber mats. Related Books Electrospun Nanofibers for Bio

The Recent Research in Restorative Dental Materials Reprint presents a comprehensive collection of high-quality research focused on the latest advances in materials science applied to restorative dentistry. This curated body of work highlights the transformative developments in dental materials that have emerged in recent years, including innovations in composite resins, glass–ionomer cements, hybrid ceramics, zirconia, and other restorative substrates. Contributors explore how modern material compositions and advanced manufacturing techniques influence mechanical performance, clinical outcomes, and long-term durability in the oral environment. The Reprint also encompasses studies on cutting-edge application methods, such as digital workflows incorporating CAD/CAM systems, minimally invasive restorative approaches, novel polymerization protocols, and the role of environmental and biological factors affecting material longevity. In vitro and in vivo research, clinical investigations, communications, and reviews are represented, offering a multidisciplinary perspective on current challenges and opportunities in restorative dental materials. This Reprint is an essential resource for researchers, clinicians, and material scientists dedicated to advancing the science and practice of restorative dentistry.

Today, new technologies bring with them an everchanging panorama, forcing us to constantly update our knowledge. For this reason, quality education is necessary in all areas of knowledge and at all educational levels. The quality of our educational systems and the questions raised by reviewing whether our educational institutions offer quality education or not are some of the main reasons why quality education is a topic that, in recent years, has captured the interest of governments, researchers and lecturers, among others. This issue brings together different socioeducational actors with their concerns for and commitments to higher education, in order to achieve the aim of providing people with the competencies necessary to adapt to a changing and competitive world, in which the individual needs to engage in lifelong learning and where education must align with sustainable development goals, such as democracy, justice and equality. All of this provides us with a scenario for reflec

Genitourinary cancers are diseases affecting an increasing number of people, the diagnosis and treatment of which are currently undergoing fast and sometimes dramatic changes due to the current landscape of suboptimal management of these diseases. A characteristic feature of urological cancer treatment is the significant heterogeneity of patients (including different stages of local advancement, different locations of metastases, the heterogeneity of pathological findings, etc.). Therefore, in modern urologic oncology, there remains the unmet need of predicting the response to modern treatments, and new diagnostic methods, including but not limited to point-of-care diagnostics, represent a challenge to current guidelines and require verification. Additionally, further development awaits as far as sufficient neoadjuvant and adjuvant treatment in the perioperative setting are concerned. However, recent advancements in systematic treatment, i.e., immunotherapy, have shed light on new treatment paradigms to be implemented in various clinical scenarios, including localized disease, and recent progress in minimally invasive surgical techniques has lead to revisions to the treatment of many urological tumors.

Cancer is a leading cause of death worldwide, claiming millions of lives each year. Cancer biology is an essential research field to understand how cancer develops, evolves, and responds to therapy. By taking advantage of a series of “omics” technologies (e.g., genomics, transcriptomics, and epigenomics), computational methods in bioinformatics and machine learning can help scientists and researchers to decipher the complexity of cancer heterogeneity, tumorigenesis, and anticancer drug discovery. Particularly, bioinformatics enables the systematic interrogation and analysis of cancer from various perspectives, including genetics, epigenetics, signaling networks, cellular behavior, clinical manifestation, and epidemiology. Moreover, thanks to the influx of next-generation sequencing (NGS) data in the postgenomic era and multiple landmark cancer-focused projects, such as The Cancer Genome Atlas (TCGA) and Clinical Proteomic Tumor Analysis Consortium (CPTAC), machine learning has a uniq

The number of patient health data has been estimated to have reached 2314 exabytes by 2020. Traditional data analysis techniques are unsuitable to extract useful information from such a vast quantity of data. Thus, intelligent data analysis methods combining human expertise and computational models for accurate and in-depth data analysis are necessary. The technological revolution and medical advances made by combining vast quantities of available data, cloud computing services, and AI-based solutions can provide expert insight and analysis on a mass scale and at a relatively low cost. Computational intelligence (CI) methods, such as fuzzy models, artificial neural networks, evolutionary algorithms, and probabilistic methods, have recently emerged as promising tools for the development and application of intelligent systems in healthcare practice. CI-based systems can learn from data and evolve according to changes in the environments by taking into account the uncertainty characteri

Pharmaceuticals, due to their pseudo-persistence and biological activity as well as their extensive use in human and veterinary medicine, are a class of environmental contaminants that is of emerging concern. In contrast to some conventional pollutants, they are continuously delivered at low levels, which might give rise to toxicity even without high persistence rates. These chemicals are designed to have a specific physiological mode of action and to resist frequently inactivation before exerting their intended therapeutic effect. These features, among others, result in the bioaccumulation of pharmaceuticals which are responsible for toxic effects in aquatic and terrestrial ecosystems. It is extremely important to know how to remove them from the environment and/or how to implement procedures or treatments resulting in their biological inactivation. Although great advances have been made in their detection in aquatic matrices, there remains limited analytical methodologies available

This Special Issue delves into the ever-evolving realm of pharmacy practice and administration. It includes rigorously peer-reviewed review articles and original research papers that assess current practices, explore advancements in medication management, discuss developments in therapeutics, and present pharmaceutical science research aimed at enhancing both practice and administration, including aspects of social and administrative pharmacy. Related Books Pharmacy Practice and Administration Public Health & Healthcare Clinical Pharmacology and Pharmacy of Antimicrobial Agents Biology & Life Sciences Communication in Pharmacy Practice Public Health & Healthcare Recent Advances in Secondary Processing of Pharmaceutical Powders Engineering Antimicrobial Prescribing and Stewardship, 2nd Volume Medicine & Pharmacology The recommendations have been generated using an AI system. About: About MDPI Books Advisory Board Legal Information: MDPI Privacy Policy Terms and Conditions Terms